LEO Pharma Open Innovation

Eczema targets we already know about

 

 

 

   
Consolidated list of targets Link 1 Link 2 Link 3
5-HT1A receptor (agonist) https://www.targetvalidation.org/target/ENSG00000178394     
5-HT2B receptor https://www.targetvalidation.org/target/ENSG00000135914     
beta adrenergic receptor https://www.targetvalidation.org/target/ENSG00000043591  https://www.targetvalidation.org/target/ENSG00000169252  https://www.targetvalidation.org/target/ENSG00000188778 
Aryl hydrocarbon receptor (Ahr) (agonist target) https://www.targetvalidation.org/target/ENSG00000106546     
Calcineurin pathway https://www.targetvalidation.org/target/ENSG00000088832  https://www.targetvalidation.org/target/ENSG00000196262   
Cannabinoid receptor (agonist target) https://www.targetvalidation.org/target/ENSG00000118432  https://www.targetvalidation.org/target/ENSG00000188822   
C-C chemokine receptor type 1 (CCR1) https://www.targetvalidation.org/target/ENSG00000163823     
CD11a/CD18 (LFA-1) https://www.targetvalidation.org/target/ENSG00000005844  https://www.targetvalidation.org/target/ENSG00000160255   
Chymase(s) https://www.targetvalidation.org/target/ENSG00000092009     
Cyclooxygenase (COX) (target for NSAIDs) https://www.targetvalidation.org/target/ENSG00000073756  https://www.targetvalidation.org/target/ENSG00000095303   
E,L,P selectins https://www.targetvalidation.org/target/ENSG00000007908  https://www.targetvalidation.org/target/ENSG00000188404  https://www.targetvalidation.org/target/ENSG00000174175 
Galectin 3  https://www.targetvalidation.org/target/ENSG00000131981     
GATA3  https://www.targetvalidation.org/target/ENSG00000107485     
Glucocorticoid receptor (agonist target) https://www.targetvalidation.org/target/ENSG00000113580     
Histamine H1 receptor  https://www.targetvalidation.org/target/ENSG00000196639     
Histamine H2 receptor  https://www.targetvalidation.org/target/ENSG00000113749     
Histamine H4 receptor (H4R) https://www.targetvalidation.org/target/ENSG00000134489     
immunoglobulin E (IgE)      
Inosine monophosphate dehydrogenase (IMPDH) https://www.targetvalidation.org/target/ENSG00000106348  https://www.targetvalidation.org/target/ENSG00000178035   
Interferon gamma receptor (agonist; IFN-g) https://www.targetvalidation.org/target/ENSG00000027697  https://www.targetvalidation.org/target/ENSG00000159128   
Interleukin 12/23 (IL-12/23) https://www.targetvalidation.org/target/ENSG00000113302     
Interleukin 13 (IL-13)  https://www.targetvalidation.org/target/ENSG00000169194     
Interleukin 17 C (IL-17C) (Phase 1 results only)  https://www.targetvalidation.org/target/ENSG00000124391     
Interleukin 17A (IL-17A) https://www.targetvalidation.org/target/ENSG00000112115       
Interleukin 22 (IL-22) https://www.targetvalidation.org/target/ENSG00000127318     
Interleukin 31 receptor (IL-31R)  https://www.targetvalidation.org/target/ENSG00000164509     
Interleukin 33 (IL-33) https://www.targetvalidation.org/target/ENSG00000137033     
Interleukin 4 receptor alpha (IL-4Ra) https://www.targetvalidation.org/target/ENSG00000077238     
Interleukin 5 (IL-5) https://www.targetvalidation.org/target/ENSG00000113525     
JAK inhibitors (including JAK1 specifik and pan-JAK (JAK1,JAK2,JAK3,TYK2) https://www.targetvalidation.org/target/ENSG00000162434  https://www.targetvalidation.org/target/ENSG00000105639  https://www.targetvalidation.org/target/ENSG00000105397 
Kappa-opioid receptor (agonist target)  https://www.targetvalidation.org/target/ENSG00000082556     
Leukotriene pathway (synthesis of LTB4, LTC4 and receptors)      
Liver X Receptor (LXR) (agonist target) https://www.targetvalidation.org/target/ENSG00000025434  https://www.targetvalidation.org/target/ENSG00000131408   
Neurokinin 1 receptor (NK1R)  https://www.targetvalidation.org/target/ENSG00000115353     
Neutrophil elastase https://www.targetvalidation.org/target/ENSG00000197561     
NFkappaB pathway      
Nitric oxide synthase (NOS) https://www.targetvalidation.org/target/ENSG00000007171     
Opioid receptors https://www.targetvalidation.org/target/ENSG00000116329  https://www.targetvalidation.org/target/ENSG00000082556  https://www.targetvalidation.org/target/ENSG00000112038 
OX40/OX40L  https://www.targetvalidation.org/target/ENSG00000186827  https://www.targetvalidation.org/target/ENSG00000117586  
Phosphodiesterase 4 (PDE4) https://www.targetvalidation.org/target/ENSG00000065989  https://www.targetvalidation.org/target/ENSG00000184588  https://www.targetvalidation.org/target/ENSG00000105650 
Phospholipase A2 (PLA2)  https://www.targetvalidation.org/search?src=q:sPLA2     
Platelet activating factor receptor (PAFR) https://www.targetvalidation.org/target/ENSG00000169403     
Prostaglandin D2 receptor (DP1,DP1) https://www.targetvalidation.org/target/ENSG00000168229  https://www.targetvalidation.org/target/ENSG00000183134   
Retinoic acid receptor (RAR) (agonist target) https://www.targetvalidation.org/target/ENSG00000131759  https://www.targetvalidation.org/target/ENSG00000077092  https://www.targetvalidation.org/target/ENSG00000172819 
Sphingosine 1 phosphate receptor (S1PR) https://www.targetvalidation.org/search?src=q:s1pr     
Thymic stromal lymphopoietin (TSLP)  https://www.targetvalidation.org/target/ENSG00000145777     
TNF-alpha https://www.targetvalidation.org/target/ENSG00000232810  https://www.targetvalidation.org/target/ENSG00000067182  https://www.targetvalidation.org/target/ENSG00000028137 
Toll like receptor 2 (TLR2) https://www.targetvalidation.org/target/ENSG00000137462     
Toll like receptor 4 (TLR4) https://www.targetvalidation.org/target/ENSG00000136869     
Toll like receptor 9 (TLR9) https://www.targetvalidation.org/target/ENSG00000239732     
TrkA https://www.targetvalidation.org/target/ENSG00000198400     
Vanilloid VR1 Receptor (TRPV1)   https://www.targetvalidation.org/target/ENSG00000196689     
Vitamin D receptor (VDR) https://www.targetvalidation.org/target/ENSG00000111424     
       
       
List of molecules (target not directly specified) Link Remarks  
Examples of drugs that could have a mode-of-action that includes unknown targets  
Antimicrobials (antibacterials, antiseptics, antifungals)      
Azathioprine (purin analog) https://www.drugbank.ca/drugs/DB00993     
Cromoglycate https://www.drugbank.ca/drugs/DB01003     
Dihomo gamma linolenic acid (DGLA) https://www.drugbank.ca/drugs/DB00154     
Docosahexaenoic acid (DHA) https://www.drugbank.ca/drugs/DB03756     
Doxepin https://www.drugbank.ca/drugs/DB01142     
Heparin; heparinoids https://www.drugbank.ca/drugs/DB01109  https://en.wikipedia.org/wiki/Heparinoid   
Isoprenylcysteine analogue (IPC)       
Levomenol (bisabolol) https://www.drugbank.ca/drugs/DB13153     
Licochalcone https://en.wikipedia.org/wiki/Licochalcone_A     
Lipoxin A4 analogs https://en.wikipedia.org/wiki/Lipoxin     
Methotrexate https://www.drugbank.ca/drugs/DB00563     
Miltefosine https://www.drugbank.ca/drugs/DB09031     
Nedocromil https://www.drugbank.ca/drugs/DB00716     
Olopatadine https://www.drugbank.ca/drugs/DB00768     
Pramoxine https://www.drugbank.ca/drugs/DB09345     
Resveratrol analogs http://adisinsight.springer.com/drugs/800018462     
Sorbityl furfural palmitate      
Statins (atorvastatin etc.) https://www.drugbank.ca/drugs/DB01076     
Suplatast http://adisinsight.springer.com/drugs/800001698     
Thymomodulin, thymopentin, thymostimulin https://www.drugbank.ca/drugs/DB11996     
Trimipramine, trimeprazine https://www.drugbank.ca/drugs/DB00726     
Vitamin B12 https://www.drugbank.ca/drugs/DB00115